Blar i forfatter "Mwaikono, Kilaza S."

Viser treff 1-2 av 2

    • Composition of gut microbiota of children and adolescents with perinatal HIV infection taking antiretroviral therapy in Zimbabwe 

      Flygel, Trym Thune; Sovershaeva, Evgeniya; Classen-Weitz, Shantelle; Hjerde, Erik; Mwaikono, Kilaza S.; Odland, Jon Øyvind; Ferrand, Rashida A.; McHugh, Grace; Gutteberg, Tore Jarl; Nicol, Mark P.; Cavanagh, Jorunn Pauline; Flægstad, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-24)
      <p><i>Background - </i>Human immunodeficiency virus (HIV) infection causes impairment of the gastrointestinal barrier, with substantial depletion of CD4<sup>+</sup> T cells in the gut. Antiretroviral therapy (ART) restores CD4<sup>+</sup> counts and may have beneficial effects on gut microbiota in adults. Little is known about effect of long-term ART on gut microbiome in HIV-infected children. We ...

    • Sputum bacterial load and bacterial composition correlate with lung function and are altered by long-term azithromycin treatment in children with HIV-associated chronic lung disease 

      Abotsi, Regina E.; Dube, Felix S.; Rehman, Andrea M.; Claassen-Weitz, Shantelle; Xia, Yao; Simms, Victoria; Mwaikono, Kilaza S.; Gardner-Lubbe, Sugnet; McHugh, Grace; Ngwira, Lucky G.; Kwambana-Adams, Brenda; Heyderman, Robert S.; Odland, Jon Øyvind; Ferrand, Rashida A.; Nicol, Mark P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)
      Background - Long-term azithromycin (AZM) treatment reduces the frequency of acute respiratory exacerbation in children and adolescents with HIV-associated chronic lung disease (HCLD). However, the impact of this treatment on the respiratory bacteriome is unknown.<p> <p>Method - African children with HCLD (defined as forced expiratory volume in 1 s z-score (FEV1z) less than − 1.0 with no ...